Protease inhibitor nano homogenizer

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Broadly speaking, it refers to protease moleculesactive centerA substance that binds to some functional groups on the surface, causing a decrease or even disappearance of protease activity, but does not denature the enzyme protein. fromActinomycetesSeparated from the fermentation brothLuminescent peptide、Antipain hormone、ChymotrypsinSomatostatin, suppresselastaseAldehydes, suppressantsGastric proteaseHormones, phosphoramides, etc. can respectively inhibitTrypsin、Papain proteaseChymotrypsin, elastaseGastric proteaseVarious enzymes such as metalloproteinasesproteaseAll belong to protease inhibitors.

proteaseIt's human immunodeficiencyvirus gene codeA unique type withinDong DongAcylprotease, itseffectYes, it willgeneAndgeneProteins produced by expressionsplittingBecoming activevirusStructural proteins and enzymes areinhibitionHⅣvirus copyThe key substance.proteaseinhibitionMedication is a form of treatmentAIDSChemical counterpartsmedicine.

Protease inhibitor genuspolypeptideClasschemical compoundAs an important component of anti HIV drug combination therapy, it was developed in the mid-1990slater stageTheNew productionThe difficulty of drug synthesis process is also the main reason for the high cost of anti-H IV treatment, which is known as "must overcome barriers". Protease inhibitors mainly include: nefinavir, saquinamivir, indinavir, and aprinavirRitonavirLopinavir and its compound preparations.

It is a peptide based compound that can competitively inhibit proteinsenzymatic activityOr as a complementary proteinenzymatic activityPoint inhibitors. This type of drug can inhibit the activity of proteases, mainly acting onAIDS virusIn the post replication stage, due to the inhibition of protease, it is prevented from infectingCD4 nucleusFormed in the middleDNACannot gather and release.

H IV gradeRetrovirusGene encoded precursor proteinneedUnder the action of protease, it is cleaved into functional formstructural proteinOnly then can it be assembled into complete virus particles. Protease inhibitors can bind to viral protease catalytic genes to inhibit enzyme activity, leading to protein degradationWhite frontThe body cannot crack or formmatureViral body.

Dr. Joan Stephenson is in the United StatesMedical ScienceWill《Medical ScienceAn article published in the Journal of News and Opinion states that researchers in the United States, Canada, and Australia have found that some patients receiving anti-H IV treatment develop symptoms after taking protease inhibitorsFatAbnormal distribution.
Researchers have found that after taking protease inhibitors for 3 months or more, some patientsweightUnder unchanged conditions, fat appearedorganizationAbnormal sedimentation, manifested as“buffaloBack "(referring to the fat at the bottom of the neck)organization）Pot shaped abdomen or“full moonThe face. However, some other patients experienced fat loss in their limbs or face after taking protease inhibitors. The above symptoms are present in KexingSyndromeVery common among patients. ThisSyndromeIt's becauseserum corticosteroneCaused by abnormal elevation, but not found in these patientsserumcorticosteroneEvidence of elevation. There are four types of protease inhibitors that cause abnormal fat deposition: indinavir, nelfinavir, ritonavir, and saquinavir. National Health Agency of the United States（NIH）Researchers conducted a study on 10 patients with increased abdominal circumferenceCT scanIt was found that after taking indinavir, fat did not deposit inskinInstead, it deposits around the abdominal organs. It is still unclear how protease inhibitors cause the above symptoms. Some studies suggest that protease inhibitors may affectmetabolizeFunction, causingTriglyceridesAndblood sugarThe increaseinsulinResistance anddiabetesHowever, these abnormalities were not found in patients with fat deposition. Similarly, fat deposits inChange dressingIt is also unclear whether it is reversible afterwards.
Therefore, researchers believe that long-term clinical trials and after-sales supervision should be conducted for these drugs to clarify the causes of this complication happenRate and possible treatment methods.

XMD2000 imported ultra-high shear grinding and dispersing machine
Grinding and dispersing machine is a high-tech product composed of colloid grinding and dispersing machines.

The first level consists of three-level sawtooth protrusions and grooves with increasing precision. The stator can be infinitely adjusted to the desired distance between the rotors. Under enhanced fluid turbulence. The groove can change direction at each level.
The second stage is composed of a stator. The design of the dispersing head also effectively meets the needs of substances with different viscosities and particle sizes. The difference in the design of the stator and rotor (emulsifying head) between online and batch machines is mainly due to the requirements for conveying performance. It is particularly important to note that the difference between coarse precision, medium precision, fine precision, and other types of working heads is not only the arrangement of specified rotor teeth, but also an important difference in the geometric characteristics of different working heads. The width of the slot and other geometric features can alter the different functions of the stator and rotor working heads.

The following is a model table for reference:

Protease inhibitor nano homogenizer